Publications 

2017

  • Wilson, D. M., Rieckher, M., Williams, A. B. & Schumacher, B. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Nucleic Acids Res doi:10.1093/nar/gkx660
  • Rieckher, M., Bujarrabal, A., Doll, M. A., Soltanmohammadi, N. & Schumacher, B. A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes. J Cell Physiol  [Epub ahead of print] doi:10.1002/jcp.25979
  • Hahn, O., ..., Beyer, A., Reik, W. & Partridge, L. Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biology 18, 56 (2017).
  • Williams, A. B. & Schumacher, B. DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity. Mech Ageing Dev 165, Part A, 27–32 (2017).
  • Barzilai, A., Schumacher, B. & Shiloh, Y. Genome instability: Linking ageing and brain degeneration. Mech Ageing Dev 161, Part A, 4–18 (2017).

2016

  • Ackermann, L., …, Schumacher, B. & Hoppe, T. E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis. Nat Struct Mol Biol 23, 995-1002 (2016).
  • Fernández-Majada, V., …, Schumacher, B. & Pasparakis, M. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun 7, 12508 (2016).
  • Johnsen, M, …, Benzing, T., …, Antebi, A.,…, & Müller, R.-M. Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage. PLoS ONE 11, e0161315 (2016).
  • Essers, P., Tain, L.S., … & Partridge, L. Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice. Sci Rep. 6, 30290 (2016).
  • Liu, Y., Beyer, A. & Aebersold, R. On the Dependency of Cellular Protein Levels on mRNA Abundance. Cell 165, 535–550 (2016).
  • Babu, V. & Schumacher, B. A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. DNA Repair 41, 8-15 (2016).
  • Nakamura, S., …, Dieterich, C. & Antebi, A. Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. Nat Commun 7, 10944 (2016).
  • Oliverio, M., …, Brüning, J.C. & Kornfeld, J.-W. Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. Nat Cell Biol 18, 328–336 (2016)
  • Afschar, S., … & Partridge, L. Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proc Natl Acad Sci USA. 113, 1321-1326 (2016). 
  • Ribezzo, F., Shiloh, Y. & Schumacher, B. Systemic DNA damage responses in aging and diseases. Semin Cancer Biol. 37-38, 25-35 (2016).
  • Gatto, L., … & Beyer, A. Testing and Validation of Computational Methods for Mass Spectrometry. J Proteome Res. 15, 809-814 (2016).

2015

  • Garmhausen, M., …., & Habermann, B. Virtual pathway explorer (viPEr) and pathway enrichment analysis tool (PEANuT): creating and analyzing focus networks to identify cross-talk between molecules and pathways. BMC Genomics 16, 790 (2015).
  • Edifizi, D. & Schumacher, B. Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms. Biomolecules 5, 1855–1869 (2015).
  • Ermolaeva, M. A., Dakhovnik, A. & Schumacher, B. Quality control mechanisms in cellular and systemic DNA damage responses. Ageing Research Reviews 23, Part A, 3–11 (2015).
  • Torgovnick, A. & Schumacher, B. DNA repair mechanisms in cancer development and therapy. Front Genet 6, 157 (2015).
  • Stephan, J., Stegle, O. & Beyer, A. A random forest approach to capture genetic effects in the presence of population structure. Nat Commun 6:7432 (2015).
  • Denzel, M. S. & Antebi, A. Hexosamine pathway and (ER) protein quality control. Current Opinion in Cell Biology 33, 14–18 (2015).
  • Frommolt, P. & Schumacher, B. Wormpath: searching for molecular interaction networks in Caenorhabditis elegans. Source Code Biol Med 10, 5 (2015).
  • Castells-Roca, L., Mueller, M. M. & Schumacher, B. Longevity through DNA damage tolerance. Cell Cycle 14, 467–468 (2015).

2014

  • Babu, V., Hofmann, K. & Schumacher, B. A C. elegans homolog of the Cockayne syndrome complementation group A gene. DNA Repair 24, 57–62 (2014).
  • Mueller, M. M. , …, Mueller, R.U., Frommolt, P.,…, Benzing, T., Schermer, B. & Schumacher, B. DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol 16, 1168–1179 (2014).
  • Rinschen, M. M., …, Schermer, B., Benzing, T. & Brinkkoetter, P.T. Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics 15, 1326–1331 (2014).
  • Wolters, S., Ermolaeva M. A., Bickel, J. S., Fingerhut, J. M., Khanikar, J., Chan, R.C. & Schumacher, B. Loss of Caenorhabditis elegans BRCA1 Promotes Genome Stability During Replication in smc-5 Mutants. Genetics 196, 985–999 (2014).
  • Denzel, M. S. Storm N.J., Gutschmidt A., Baddi R., Hinze Y., Jarosch E., Sommer T., Hoppe T., Antebi A. Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life. Cell 156, 1167–1178 (2014).
  • Fernandes de Abreu, D. A., …, Antebi, A., … et al. An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology. PLoS Genet 10, e1004225 (2014).
  • Łuksza, M. & Lässig, M. A predictive fitness model for influenza. Nature 507, 57–61 (2014).
  • Ermolaeva, M. A. & Schumacher, B. Systemic DNA damage responses: organismal adaptations to genome instability. Trends Genet. 30, 95–102 (2014).
  • Piper, M. D. W. , … & Partridge, L. A holidic medium for Drosophila melanogaster. Nat Methods 11, 100–105 (2014).

2013

  • Ermolaeva, M. A., Segref, A., Dakhovnik, A., Ou, H.-L., Schneider J. I., Utermöhlen, O., Hoppe, T. & Schumacher, B. DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 501, 416-420 (2013).
  • Schermer, B., Bartels, V., Frommolt, P., Habermann, B., Braun, F., Schulze, J. L., Roodbergen, M., Hoeijmakers, J. H. J., Schumacher, B., Nürnberg, P., Dollé, M. E. T., Benzing, T., Müller, R.-U. & Kurschat C. E. Transcriptional profiling reveals progeroid Ercc1 -/Δ mice as a model system for glomerular aging. BMC Genomics 14, 559 (2013).
  • Magner, D. B., Wollam, J., Shen, Y., Hoppe, C., Li, D., Latza, C., Rottiers, V., Hutter, H. & Antebi, A. The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans. Cell Metabolism 18, 212–224 (2013).
  • Heestand, B.N., Shen, Y., Liu, W., Magner, D.B., Storm, N., Meharg, C., Habermann, B. & Antebi, A. Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9, e1003651 (2013).
  • Weghorn, D. & Lässig, M. Fitness landscape for nucleosome positioning. Proc Natl Acad Sci USA. 110,10988–10993 (2013).
  • Antebi, A. Regulation of longevity by the reproductive system. Exp Gerontol. 48, 596–602 (2013).
  • Riedel, N. & Berg, J. Statistical mechanics approach to the sample deconvolution problem. Phys Rev. E 87, 042715 (2013).
  • Wolters, S. & Schumacher, B. Genome maintenance and transcription integrity in aging and disease. Front Genet. 4, 19 (2013).
  • Klironomos, F. D. & Berg, J. Quantitative Analysis of Competition in Posttranscriptional Regulation Reveals a Novel Signature in Target Expression Variation. Biophys. J. 104, 951–958 (2013).
  • Nourmohammad, A., Schiffels, S. & Lässig, M. Evolution of molecular phenotypes under stabilizing selection. J Stat Mech. 2013, P01012 (2013).

2012

  • Shen, Y., Wollam, J., Magner, D., Karalay, O. & Antebi, A. A Steroid Receptor–MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad. Science 338, 1472–1476 (2012).
  • Reinhardt, H. C. & Schumacher, B. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet. 28, 128–136 (2012).