• Tain, L. S., …, Beyer, A. & Partridge, L. Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. eLife 10, e67275 (2021).
  • Lackner, A., …, Beyer, A. & Leeb, M. Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency. EMBO J. 40, e105776 (2021).


  • Weigelt, C. M., …, Dieterich, C., Grönke, S. & Partridge, L. An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila. Mol. Cell 79, 268-279.e5 (2020).
  • Tain, L. S., …, Grönke, S. & Partridge, L. Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. Aging Cell 19, e13043 (2020).


  • Zhou, Y., …, Dieterich, C., Antebi, A., Jing, N. & Shen, Y. A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing. Nat. Commun. 10, 4827 (2019).
  • Hahn, O., …, Beyer, A., Grönke, S. & Partridge, L. A nutritional memory effect counteracts the benefits of dietary restriction in old mice. Nat. Metab. 1, 1059-1073 (2019).
  • Soste, M., …, Beyer, A. & Picotti, P. Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity. Cell Systems 9, 309-320.e8 (2019).
  • Ou, H.-L., Kim, C. S., Uszkoreit, S., Wickström, S. A. & Schumacher, B. Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. Dev. Cell 50, 167-183.e8 (2019).


  • Debès, C., Leote, A. C. & Beyer, A. Computational approaches for the systematic analysis of aging-associated molecular alterations. Drug Discovery Today: Disease Models 27, 51-59 (2018).
  • Hahn, O., Stubbs, T. M., Reik, W., Grönke, S., Beyer, A. & Partridge, L. Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity. PLOS Genetics 14, e1007766 (2018).
  • Torgovnick, A., …, Schumacher, B. & Reinhardt, H. C. The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Reports 25, 1027-1039.e6 (2018).
  • Bianco, J. N. & Schumacher, B. MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO. Nucleic Acids Res 46, 6129-6139 (2018).
  • Welcker, D., ..., Benzing, T. & Höpker, K. AATF suppresses apoptosis, promotes proliferation and is critical for Kras -driven lung cancer. Oncogene 37, 1503-1518 (2018).
  • Nowak, S., ... & Krug, J. Interaction Analysis of Longevity Interventions Using Survival Curves. Biology 7, 6 (2018).
  • Rieckher, M., Bujarrabal, A., Doll, M. A., Soltanmohammadi, N. & Schumacher, B. A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes. J. Cell. Physiol. 233, 2781-2790 (2018).


  • Nguyen, H. C., Zecchina, R. & Berg, J. Inverse statistical problems: from the inverse Ising problem to data science. Advances in Physics 66, 197–261 (2017).
  • Brandt, T., ..., Partridge, L., ..., Kühlbrandt, W. Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila. eLife Sciences 6, e24662 (2017).
  • Mackmull, M.-T., ..., Beyer, A., ... & Beck, M. Landscape of nuclear transport receptor cargo specificity. Mol. Syst. Biol. 13, 962 (2017).
  • Edifizi, D. & Schumacher, B. Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging. Int. J. Mol. Sci. 18, 2329 (2017).
  • Liu, Y., ..., Beyer, A., Antonarakis, S.E. & Aebersold, R. Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells. Nat. Commun. 8, 1212 (2017).
  • Tain, L. S., ..., Dieterich, C., ..., Beyer, A. & Partridge, L. A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance. Mol. Syst. Biol. 13, 939 (2017).
  • Wilson, D. M., Rieckher, M., Williams, A. B. & Schumacher, B. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Nucleic Acids Res. 46, 9467-9480 (2017).
  • Edifizi, D., Nolte, H., ..., Schumacher, B. Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans. Cell Rep. 20, 2026-2043 (2017).
  • Hahn, O., ..., Beyer, A., Reik, W. & Partridge, L. Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biol. 18, 56 (2017).
  • Williams, A. B. & Schumacher, B. DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity. Mech. Ageing Dev. 165, Part A, 27–32 (2017).
  • Barzilai, A., Schumacher, B. & Shiloh, Y. Genome instability: Linking ageing and brain degeneration. Mech. Ageing Dev. 161, Part A, 4–18 (2017).


  • Ackermann, L., …, Schumacher, B. & Hoppe, T. E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis. Nat. Struct. Mol. Biol. 23, 995-1002 (2016).
  • Soultoukis, G. A. & Partridge, L. Dietary Protein, Metabolism, and Aging. Annu. Rev. Biochem. 85, 5–34 (2016).
  • Fernández-Majada, V., …, Schumacher, B. & Pasparakis, M. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat. Commun. 7, 12508 (2016).
  • Johnsen, M, …, Benzing, T., …, Antebi, A.,…, & Müller, R.-M. Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage. PLoS ONE 11, e0161315 (2016).
  • Essers, P., Tain, L.S., … & Partridge, L. Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice. Sci Rep. 6, 30290 (2016).
  • Liu, Y., Beyer, A. & Aebersold, R. On the Dependency of Cellular Protein Levels on mRNA Abundance. Cell 165, 535–550 (2016).
  • Babu, V. & Schumacher, B. A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. DNA Repair 41, 8-15 (2016).
  • Nakamura, S., …, Dieterich, C. & Antebi, A. Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. Nat. Commun. 7, 10944 (2016).
  • Oliverio, M., …, Brüning, J.C. & Kornfeld, J.-W. Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. Nat. Cell Biol. 18, 328–336 (2016)
  • Afschar, S., … & Partridge, L. Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proc. Natl. Acad. Sci. U.S.A. 113, 1321-1326 (2016). 
  • Ribezzo, F., Shiloh, Y. & Schumacher, B. Systemic DNA damage responses in aging and diseases. Semin. Cancer Biol. 37-38, 25-35 (2016).
  • Gatto, L., … & Beyer, A. Testing and Validation of Computational Methods for Mass Spectrometry. J. Proteome Res. 15, 809-814 (2016).


  • Garmhausen, M., …., & Habermann, B. Virtual pathway explorer (viPEr) and pathway enrichment analysis tool (PEANuT): creating and analyzing focus networks to identify cross-talk between molecules and pathways. BMC Genomics 16, 790 (2015).
  • Edifizi, D. & Schumacher, B. Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms. Biomolecules 5, 1855–1869 (2015).
  • Ermolaeva, M. A., Dakhovnik, A. & Schumacher, B. Quality control mechanisms in cellular and systemic DNA damage responses. Ageing Res. Rev. 23, Part A, 3–11 (2015).
  • Torgovnick, A. & Schumacher, B. DNA repair mechanisms in cancer development and therapy. Front. Genet 6, 157 (2015).
  • Stephan, J., Stegle, O. & Beyer, A. A random forest approach to capture genetic effects in the presence of population structure. Nat. Commun. 6:7432 (2015).
  • Denzel, M. S. & Antebi, A. Hexosamine pathway and (ER) protein quality control. Curr. Op. Cell Biol. 33, 14–18 (2015).
  • Frommolt, P. & Schumacher, B. Wormpath: searching for molecular interaction networks in Caenorhabditis elegans. Source Code Biol Med 10, 5 (2015).
  • Castells-Roca, L., Mueller, M. M. & Schumacher, B. Longevity through DNA damage tolerance. Cell Cycle 14, 467–468 (2015).


  • Babu, V., Hofmann, K. & Schumacher, B. A C. elegans homolog of the Cockayne syndrome complementation group A gene. DNA Repair 24, 57–62 (2014).
  • Mueller, M. M. , …, Mueller, R.U., Frommolt, P.,…, Benzing, T., Schermer, B. & Schumacher, B. DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat. Cell Biol. 16, 1168–1179 (2014).
  • Rinschen, M. M., …, Schermer, B., Benzing, T. & Brinkkoetter, P.T. Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics 15, 1326–1331 (2014).
  • Wolters, S., Ermolaeva M. A., Bickel, J. S., Fingerhut, J. M., Khanikar, J., Chan, R.C. & Schumacher, B. Loss of Caenorhabditis elegans BRCA1 Promotes Genome Stability During Replication in smc-5 Mutants. Genetics 196, 985–999 (2014).
  • Denzel, M. S. Storm N.J., Gutschmidt A., Baddi R., Hinze Y., Jarosch E., Sommer T., Hoppe T., Antebi A. Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life. Cell 156, 1167–1178 (2014).
  • Fernandes de Abreu, D. A., …, Antebi, A., … et al. An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology. PLoS Genet 10, e1004225 (2014).
  • Luksza, M. & Lässig, M. A predictive fitness model for influenza. Nature 507, 57–61 (2014).
  • Ermolaeva, M. A. & Schumacher, B. Systemic DNA damage responses: organismal adaptations to genome instability. Trends Genet. 30, 95–102 (2014).
  • Piper, M. D. W. , … & Partridge, L. A holidic medium for Drosophila melanogaster. Nat. Methods 11, 100–105 (2014).


  • Ermolaeva, M. A., Segref, A., Dakhovnik, A., Ou, H.-L., Schneider J. I., Utermöhlen, O., Hoppe, T. & Schumacher, B. DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 501, 416-420 (2013).
  • Schermer, B., Bartels, V., Frommolt, P., Habermann, B., Braun, F., Schulze, J. L., Roodbergen, M., Hoeijmakers, J. H. J., Schumacher, B., Nürnberg, P., Dollé, M. E. T., Benzing, T., Müller, R.-U. & Kurschat C. E. Transcriptional profiling reveals progeroid Ercc1 -/Δ mice as a model system for glomerular aging. BMC Genomics 14, 559 (2013).
  • Magner, D. B., Wollam, J., Shen, Y., Hoppe, C., Li, D., Latza, C., Rottiers, V., Hutter, H. & Antebi, A. The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans. Cell Metabolism 18, 212–224 (2013).
  • Heestand, B.N., Shen, Y., Liu, W., Magner, D.B., Storm, N., Meharg, C., Habermann, B. & Antebi, A. Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9, e1003651 (2013).
  • Weghorn, D. & Lässig, M. Fitness landscape for nucleosome positioning. Proc. Natl. Acad. Sci. U.S.A. 110,10988–10993 (2013).
  • Antebi, A. Regulation of longevity by the reproductive system. Exp. Gerontol. 48, 596–602 (2013).
  • Riedel, N. & Berg, J. Statistical mechanics approach to the sample deconvolution problem. Phys. Rev. E 87, 042715 (2013).
  • Wolters, S. & Schumacher, B. Genome maintenance and transcription integrity in aging and disease. Front. Genet. 4, 19 (2013).
  • Klironomos, F. D. & Berg, J. Quantitative Analysis of Competition in Posttranscriptional Regulation Reveals a Novel Signature in Target Expression Variation. Biophys. J. 104, 951–958 (2013).
  • Nourmohammad, A., Schiffels, S. & Lässig, M. Evolution of molecular phenotypes under stabilizing selection. J. Stat. Mech. 2013, P01012 (2013).


  • Shen, Y., Wollam, J., Magner, D., Karalay, O. & Antebi, A. A Steroid Receptor–MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad. Science 338, 1472–1476 (2012).
  • Reinhardt, H. C. & Schumacher, B. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet. 28, 128–136 (2012).